We are very excited about our newest collaboration, “Heterogeneity in Obesity Creativity Hub: Transdisciplinary Approaches for Precision Research and Treatment,” a large collaborative project with 27 faculty from 16 departments, six schools, and five centers and institutes focused on understanding why two people who consume the same diets and exercise equally can have very different susceptibility to weight gain, with the aim of developing treatment approaches that go far beyond the “one-size-fits-all” approach that is so common. Read about the Obesity Hub here: https://research.unc.edu/creativity-hubs/winners-2018/
We focus on three specific aims:
- Conduct parallel mouse and human studies to determine whether genomic, metabolomic, and microbial factors underlie heterogeneity in weight gain and weight loss.
- Implement a precision obesity Pplot in one UNC clinic with minute-by-minute glucose, diet, and activity monitoring and treatment to lay the foundation for precision obesity care at Carolina.
- Deliver a DATA TRANSLATOR app as a platform for precision obesity science and treatment to integrate genetic, metabolomic, and diet data.
Below is the Obesity Hub team:
|Deb Tate||Co-I/Steering||SPH & SOM||Nutrition/Health Behavior|
|Steve Zeisel||Co-I/Steering||SPH & SOM/ NRI||Nutrition|
|Kimon Divaris||Co-I||Dentistry||Pediatric Dentistry|
|Stan Ahalt||Co-I||RENCI||Computer Science|
|Annie Green Howard||Co-I||SPH||Biostatistics|
|Leslie Lytle||Co-I||SPH||Health Behavior|
|Sally Stearns||Co-I||SPH||Health Policy Management|
|Rebecca Fry||Co-I||SPH||Environmental Sciences & Engineering|
|Ian Carroll||Co-I||SPH & SOM||Nutrition|
|Katie Meyer||Co-I||SPH & SOM/ NRI||Nutrition|
|Steve Hursting||Co-I||SPH & SOM/ NRI||Nutrition|
|Susan Sumner||Co-I||SPH & SOM/ NRI||Nutrition|
|John Buse||Advisory||NC TraCS||Endocrinology|
|*SPH, Gillings School of Global Public Health; SOM, School of Medicine; NRI, Nutrition|
|Research Institute; CPC, Carolina Population Center, RENCI, Renaissance Computing Institute;|
|NC TraCS, North Carolina Translational & Clinical Sciences Institute|